Curcumin
Curcumin is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family (Zingiberaceae). It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring. As a food additive, its E number is E100.
Curcumin: Curcumin is a kind of brown powder extracted and crystallized from turmeric. It can dissolve in ethanol and alkaline solutions and has good heat stability. It is widely used in pharmaceutical, cakes, candy, pickles, canned foods and other products.
Sigma C7727 Curcumin ≥94% (curcuminoid content), ≥80% (Curcumin)
Synonym: Diferuloylmethane, Diferulylmethane, Natural Yellow 3,Curcumin, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
CAS Number: 458-37-7
Linear Formula: [HOC6H3(OCH3)CH=CHCO]2CH2
Molecular Weight: 368.38
Colour Index Number: 75300
Beilstein Registry Number: 2306965
EC Number: 207-280-5
MDL number: MFCD00008365
PubChem Substance ID: 24892983
Curcumin Structure: 
Description
Biochem/physiol Actions A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Properties
vapor density 13 (vs air)
assay ≥80% (Curcumin)
≥94% (curcuminoid content)
solubility ethanol: 1 mg/mL
DMSO: 11 mg/mL
0.5 M NaOH: soluble (then immediately diluted in PBS)
Gene Information human ... APP(351), CYP1A2(1544)
storage temp. 20°C
Safety
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS MI5230000
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